Premature ovarian failure - Rejuvenate Clinic

What Causes Premature Ovarian Failure?

There are several potential causes of POF:

• Genetic factors - there may be abnormalities in the genes involved in ovulation and follicle development. Family history of POF increases risk.
• Autoimmune disease - in some cases, the immune system attacks the ovaries. Associated conditions include thyroid disorders, vitiligo, and Addison's disease.
• Radiation or chemotherapy - cancer treatments can damage ovarian follicles and lead to POF.
• Surgery - oophorectomy (ovary removal) or damage to the ovaries during abdominal surgery can cause POF.
• Infections - mumps, tuberculosis, and other viral illnesses sometimes precede POF.
• Toxins - cigarette smoking and environmental toxins are associated with earlier menopause.

In around 30% of cases, the cause is unknown (idiopathic POF).

What are the Symptoms of Premature Ovarian Failure?

The hallmark symptom is amenorrhea before age 40. Other symptoms may include:

• Hot flashes, night sweats, and other menopausal symptoms
• Infertility and inability to conceive
• Vaginal dryness
• Decreased libido
• Mood changes, depression, and emotional instability
• Osteoporosis at an earlier age

How is POF Diagnosed?

POF is diagnosed through blood tests, including:

Test	Result
Follicle stimulating hormone (FSH)	Abnormally high
Estradiol	Low in affected women
Anti-ovarian antibodies	May be present if autoimmune POF
Karyotype	To check for chromosomal abnormalities

Pelvic ultrasound may show small ovaries with few remaining follicles. The ovaries will appear postmenopausal, even at a young age.

What is the Treatment for Premature Ovarian Failure?

While POF is not curable, treatments aim to relieve symptoms and prevent complications:

Treatment	Purpose
Hormone replacement therapy (HRT)	To relieve menopausal symptoms
Fertility medications	May stimulate ovulation in some women
Egg donation	Allows pregnancy through in vitro fertilization
Osteoporosis prevention	With calcium, vitamin D, and bisphosphonates
Treat underlying autoimmune disease	If present
Psychological support	For emotional aspects

The team at Rejuvenate Clinic understands the emotional impact of premature loss of fertility. We provide compassionate care, hormone replacement therapy, and referrals for egg donation or adoption. Our fertility specialists design personalized treatment plans to meet each patient's goals. Schedule a consultation today to discuss your options for building a family and navigating life with POF.

Conclusion

In summary, premature ovarian failure is loss of normal ovarian function before age 40, with variable causes. Symptoms include infertility, menopause, and emotional distress. Treatment addresses hormone levels, fertility, and prevention of osteoporosis. With an individualized approach, women with POF can manage symptoms and pursue parenthood through alternate means. The specialists at Rejuvenate Clinic provide holistic care to support patients through this challenging diagnosis.